Strongbow - There are a lot of factors that come into play when trying to bag a buck espically a mature one. CB375HH and Squirrelnutz make some great points.
Location is key. Do as much preseason scouting as possible. Look for heavy traffic areas with intersecting runnways, near by food sources (oak trees, apple trees, corn fields, etc..). Search for those bedding areas where you might have a chance to ambush that big buck on his way back from the nights feed. But remember that deer patterns will change as the seson gets closer. Start looking for those rub & scrape lines in the woods to find the path that big buck is taking. If you find a rub, chances are there are few more that you could almost draw a straight line through.
Once you think you've found your spot you'll want to set-up at least two different stands. This way if the wind is bad for one you can hunt the other. No matter how good you think a spot may be it will do you no good sitting there if the wind is not good. Another inportant thing to remember is the path you chose to take to get to your stand. The quickest and most direct route to your stand may not always be the best choice when trying to bag a big buck. You're not going to want to walk right through a bedding area to get to your stand. You also want to pay attention to wind direction when entering. Try to keep the wind at your face so you don't spook anything going in.
Another important factor is scent control. You'll have to be pretty anal about this to increase your chances of seeing that big buck. My best advice here is to do some research. There are a lot of products out there to choose from. Everything from laundry detergent, scnet bags to store your hunting clothes in, scent lock clothing, and scent sprays. Something else I forgot to mention. While you're doing your scouting its also important not to spread your scent all over the woods. Get yourself a pair of rubber boats, this will help.
Hopefully this will get you started. Good luck!